Natural hydrogen (H₂) seepages may represent a new promising source of energy for a low carbon society. Numerous geological evidences of natural H₂ seepages and accumulation are now well identified, but our knowledge of hydrogen behavior in the crust is so limited that it is not yet possible to consider exploitation of this resource. To date, there is neither exploration strategy nor any resource assessment, as practical guidelines for hydrogen targeting are missing. Here, we lay the foundation of a new targeting approach dedicated to H₂ exploration, using the Pyrenean orogenic belt and its northern foreland basin as a playground. This latter geological setting represents a promising framework to investigate a potential H₂ system, as all the conditions for H₂ generation, migration/drainage are gathered. Geophysical data indicate the presence of a massive mantle body at shallow crustal level ( < 10 km depth) below the Mauleon Bassin. This mantle body is connected to the surface by two major faults : North Pyrenean Frontal Thrust (NPFT) to the north and North Pyrenean fault (NPF) to the south. >